We are independent & ad-supported. We may earn a commission for purchases made through our links.

Advertiser Disclosure

Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.

How We Make Money

We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently from our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

How Do I Choose the Best Antihistamine for Hives?

Lainie Petersen
By Lainie Petersen
Updated May 17, 2024
Our promise to you
WiseGEEK is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGEEK, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

If you are interested in taking an antihistamine for hives, you should ideally consult with a doctor or pharmacist prior to making a selection so as to avoid possible negative drug interactions and dangerous side effects. In many cases, an over-the-counter product may work well for your condition, but in some instances you may find that you need to use a prescription antihistamine to keep your symptoms under control. When discussing your options with a health care professional, be sure to provide information about your ability to afford the cost of treatment and lifestyle information and to ask about alternatives to taking an antihistamine for hives.

Many medical experts recommend taking an oral antihistamine for hives, as these drugs are well known for being able to reduce symptoms, although it has also been noted that they do not actually cure the condition that causes hives. In many countries, over-the-counter options, such as loratadine, diphenhydramine, or desloratadine, are both inexpensive and effective. If these drugs are available to you, you may want to try them to see if they can offer relief.

Talk to your doctor or pharmacist about your lifestyle prior to using an antihistamine for hives. Some of the older types of antihistamines can cause significant drowsiness, particularly during the first few weeks after you begin taking them. This drowsiness can present a danger while driving or engaging in other tasks that require careful attention. If you are concerned about drowsiness, ask about taking one of the more modern drugs, which are less likely to cause you to be sleepy.

Other considerations when using an antihistamine for hives include the cost of purchasing and using the drug. If you live in a country that does not have a national health program that offers coverage for prescription medications, you should check to see if a prescription antihistamine is listed on your insurance company’s formulary. In situations where your insurance doesn’t cover a particular drug, ask your doctor to prescribe a drug that is covered. If you don’t have insurance or prescription drug coverage, ask your doctor about prescribing an antihistamine that is available at a low cost or in a generic form.

Sometimes, neither over-the-counter nor prescription antihistamines are entirely effective at treating hives. If this is the case for you, your doctor may be able to prescribe a combination of antihistamine drugs that can relieve your symptoms. If a drug combination doesn’t work for you, your doctor may be able to recommend an alternative to antihistamines, including steroid drugs.

WiseGEEK is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.

Discussion Comments

By bear78 — On Apr 06, 2013

I like loratadine and certirizine. These are OTC antihistamines. I mostly take them for seasonal allergies but I have taken certirizine a couple of times when I had hives due to my nut allergy. It worked fine.

I have tried most of the OTC antihistamines and I think these two have less side effects.

By candyquilt — On Apr 06, 2013

@SarahGen-- It really depends. I think they are all effective but some have more side effects than others. For example, the older type of tablet and liquid anti-histamine called diphenhydramine is effective but it causes drowsiness, so it's best not to take it during the day.

It might be a good idea to use topical antihistamine first if you can. Since hives occur on the skin, antihistamine cream might treat it better than tablet medication.

By SarahGen — On Apr 05, 2013
Which type of antihistamine is most effective for hives -- tablet, liquid or topical?
WiseGEEK, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGEEK, in your inbox

Our latest articles, guides, and more, delivered daily.